Clearly explainedEvidence-based guidance

Contact substances

Chemically induced leukoderma

Some phenols and related chemicals can cause depigmentation after repeated skin contact, initially following the exposure pattern.

In brief

Key points

  • Look for contact patterns
  • Review work and products
  • Do not self-diagnose
  • Manage exposure carefully
01

Recognising a possible pattern

Materials, adhesives, rubber, dyes and cosmetic products may be relevant. Irritant or allergic reactions and vitiligo can look similar or coexist.

02

Act systematically

Document the suspected substance and discuss it with dermatology and, where relevant, occupational health before making broad changes.

Editorial basis

Editorial basis: current AWMF S2k guideline on the diagnosis and treatment of vitiligo, register 013-093, version 2.0 dated 27 July 2026. Reviewed on 2 September 2026.

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