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Local medicines

Tacrolimus and pimecrolimus in vitiligo

Tacrolimus and pimecrolimus are topical immunomodulating medicines. Their use for vitiligo is off-label and requires clear medical explanation.

In het kort

Belangrijkste punten

  • Off-label use
  • Often considered for face and neck
  • Prescription and follow-up
  • Response is gradual
01

Why they are considered

They do not cause the skin thinning associated with prolonged corticosteroid use and can be useful on selected sensitive areas.

02

Application and precautions

Temporary warmth or stinging can occur. Schedule, duration, sun protection and any combination with light treatment are agreed with the prescriber.

Redactionele basis

Editorial basis: current AWMF S2k guideline on the diagnosis and treatment of vitiligo, register 013-093, version 2.0 dated 27 July 2026. Reviewed on 2 September 2026.

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